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To a stirred solution of 5-fluoro-4-iodo-2-(2,2,2-trifluoroethoxy)pyridine (1.06 g, 3.3 mmol), bis(pinacolato)diboron (1.67 g, 6.6 mmol), PdCl 2 (dppf) (242 mg, 0.33 mmol), and dioxane (11 ml) was added KOAc (0.97 g, 9.9 mmol)

Among many host-directed targets, host immunometabolism has emerged as one of the most attractive targets for developing new host-directed therapies

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Therefore, the clinical efficacy of these dietary nutritional factors in the treatment of AD needs to be further evaluated in clinical trials

doi:10.1038/192047a0

The most defensible reading is to treat each compounds own within-trial data as its evidence and to treat any cross-compound ranking as a hypothesis, not a result